Studies on the visual toxicity of methanol. VIII. Additional observations on methanol poisoning in the primate test object.

In a previous report from this laboratory,' mental animals without attempting a critical the complete parallelism between symptoms evaluation of the findings presented. Suffice of methyl-alcohol poisoning in the human and it to say that there are equally vocal adherin the rhesus monkey was described. In a ents of no retinal findings and of marked subsequent report' we told how the typical histologic changes in lower animals poisoned retinal edema, pupillary dilatation, and, in with methanol. Since these animals do not many cases, death occurred in methanolshow the typical signs of human poisoning. poisoned motilceys even thoughthe usual and since the dose employed is excessive in metabolic acidosiss was completely prevented comparison to the human or the monkey by administration of base. toxic dose, the point is perhaps an academic There are additional aspects of methanol one. In the case of the single monkey re' test poisoning in which the primate object ported by Birch-Hirchfeld3 and those of can be used advantageously to help clear Scott, Helz, and McCord,' there is no disup points still in some doubt. One of these crimination between findings in the monkeys areas of confusion deals with the histologic reported and in the lower animals. findings in the retina of methanol-poisoned In the cases of human methanol poisoning animals. In the first paper, a review was where eyes were studied histologically, ther presented of histologic findings in experiare similar discrepancies. Roe° claims